Differential Macrophage Polarization Promotes Tissue Remodeling and Repair in a Model of Ischemic Retinopathy. 差異性巨噬細胞極化促進缺血性視網膜病變模型中的組織重塑和修復。 節錄自https://www.nature.com/articles/srep00076
Macrophages can be polarized to M2 phenotype through IL-4/IL-13/IL-4Rα and via activating STAT6 signaling or through IL-10/IL-10R and by activating STAT3 signaling. 巨噬細胞可以通過IL-4 / IL-13 /IL-4Rα激活STAT6信號或通過IL-10 / IL-10R激活STAT3信號而極化為M2表型。 Similarly, macrophages can be polarized to M1 phenotype through gamma interferon (IFN-γ)-IFN-γR and by activating STAT1 signaling (12). 同樣,巨噬細胞可通過γ干擾素(IFN-γ)-IFN-γR並激活STAT1信號轉導至M1表型(12)。 節錄自https://iai.asm.org/content/85/3/e00939-16
M2 macrophages in kidney disease: biology, therapies, and perspectives
腎臟疾病中的M2巨噬細胞:生物學,療法和觀點
M1/M2 presenting 2 extremes of this continuum. M2 macrophages are usually termed in the literature as anti-inflammatory and wound healing.
M1 / M2代表該連續體的兩個極端。 M2巨噬細胞在文獻中通常被稱為抗炎和【傷口癒合】。
節錄自https://www.kidney-international.org/article/S0085-2538(18)30917-7/pdf
Macrophages not only play an important role in the repair of damaged nerves, but also represent a therapeutic target for treatment of peripheral nerve injury. Owing to their pro- and anti-inflammatory nature, macrophages are able to protect tissues and promote repair.
巨噬細胞不僅在受損神經的修復中起重要作用,而且還代表了周圍神經損傷的治療靶標。 由於其促炎和抗炎性質,巨噬細胞能夠保護組織並促進修復。
節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524518/